Papers
47) Magdelene Lee, James Tuck, Albert Keung, Reimaging DNA as the Code of (More Than) Life, Chemical Engineering Progress, November 2023.
46) Thomas P. Rudibaugh, Samantha R. Stuppy, Albert J. Keung, Reactive Oxygen Species Mediate Transcriptional Responses to Dopamine and Cocaine in Human Cerebral Organoids, International Journal of Molecular Sciences, 2023. View pdf. Online link.
45) Ronald C. Estridge, Jennifer E. O’Neill, Albert J. Keung, Matrigel tunes human cerebral organoid development, Organoids, 2023. View pdf. Online link.
44) Kevin Volkel, Kevin Lin, Paul Hook, Winston Timp, Albert Keung, James Tuck, FrameD: Framework for DNA-based Data Storage Design, Verification, and Validation, Bioinformatics, 2023.
43) Maria Theresa M. Fadri, Jessica B. Lee, Albert J. Keung, Summary of ChIP-Seq methods and description of an optimized ChIP-Seq protocol, Methods in Molecular Biology, 2023.
42) Z. Begum Yagci*, Gautami R. Kelkar*, Tyler J. Johnson*, Dilara Sen*, Albert J. Keung, Designing Epigenome Editors: Considerations of Biochemical and Locus Specificities, Methods in Molecular Biology, 2023.
41) Ryan W. Tam, Albert J. Keung, Profiling transcriptomic responses of human stem cell-derived medium spiny neuron-like cells to exogenous phasic and tonic neurotransmitters, Molecular and Cellular Neuroscience, 2023. View pdf. Online link.
40) Rachel R. Polak, Albert J. Keung, A molecular assessment of the practical potential of DNA-based computation, Current Opinion in Biotechnology, 2023. View pdf. Online link.
39) Linna Han*, Jessica B. Lee*, Elaine W. Indermaur, Albert J. Keung, Chaetocin disrupts the SUV39H1-HP1 interaction independent of SUV39H1 methyltransferase activity, Biochemical Journal, 2023. View pdf, Online link.
38) Ryan W. Tam, Albert J. Keung, Human pluripotent stem cell-derived medium spiny neuron-like cells exhibit gene desensitization, Cells, 11(9), 1411, 2022. View pdf, Online link.
37) Jenna N. Meanor, Albert J. Keung, Balaji M. Rao, Nimish Gera#, Yeast Display-Guided Selection of pH-Dependent Binders, Methods in Molecular Biology, 2022. View pdf, Online link.
36) Jenna N. Meanor, Albert J. Keung#, Balaji M. Rao#, Modified Histone Peptides Linked to Magnetic Beads Reduce Binding Specificity, International Journal of Molecular Sciences, 2022. View pdf, Online link.
35) Kevin Volkel, Kyle Tomek, Albert Keung, James Tuck, DINOS: Data INspired Oligo Synthesis for DNA Data Storage, Journal on Emerging Technologies in Computing Systems, 18(3), 2022. View pdf, Online link.
34) Dilara Sen*, Alexis Voulgaropoulos*, Albert J Keung, Effects of early geometric confinement on the transcriptomic profile of human cerebral organoids, BMC Biotechnology, 2021. View pdf, Online link.
33) Jessica B Lee, Leandra M Caywood, Jennifer Y Lo, Nicholas B Levering, Albert J Keung, Mapping the dynamic transfer functions of eukaryotic gene regulation, Cell Systems, 2021.View pdf, Online link.
32) Kyle J. Tomek, Kevin Volkel, Elaine W. Indermaur, James M. Tuck#, Albert J. Keung#, Promiscuous Molecules for Smarter File Operations in DNA-based Data Storage, Nature Communications, 2021, View pdf, Online link.
31) Alison C Waldman, Balaji M Rao, Albert J Keung, A platform for the interrogation of histone modifications by yeast surface display, Cell Chemical Biology, 28:1-8, 2021, View pdf, Online link.
30) Dilara Sen, Zuzana Drobna, Albert J. Keung, Evaluation of UBE3A antibodies in mice and human cerebral organoids, Scientific Reports, 2021, View pdf, Online link.
29) Karishma Matange, James M. Tuck#, Albert J. Keung#, DNA stability: A central design consideration for DNA data storage systems, Nature Communications, 2021, View pdf, Online link.
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27) Kevin N. Lin, James M. Tuck#, Albert J. Keung#, Dynamic and Scalable DNA-based information storage, Nature Communications 2020, View pdf, Online link.
26) Dilara Sen, Albert J. Keung, Capturing complex epigenetic phenomena through human multicellular systems, Current Opinion in Biomedical Engineering, 2020, View pdf, Online link.
25) Chunyu Liao, Fani Ttofali, Rebecca Slotkowski, Steven Denny, Taylor Cecil, Ryan Leenay, Albert J. Keung, Chase Beisel, Modular, One-pot assembly of CRISPR arrays enables library generation and reveals factors influencing crRNA biogenesis, In press at Nature Communications, 2019. Preprint at Biorxiv, doi: 10.1101/312421
24) Kyle J. Tomek*, Kevin Volkel*, Alexander Simpson, Austin G. Hass, Elaine W. Indermaur, James Tuck#, Albert Keung#, Driving the scalability of DNA-based information storage systems. ACS Synthetic Biology. May 22, 2019. View pdf. Online link.
23) Minhee Park, Nikit Patel, Albert J. Keung#, Ahmad S. Khalil#, Engineering Epigenetic Regulation Using Synthetic Read-Write Modules, Cell, 2019, 176:1-12. View pdf. Online link. Research Highlight in Nature Review Genetics (pdf), Nature Methods (pdf).
22) Albert J. Keung, The untapped information of the epigenome, Chemical Engineering Progress, September 2018. View pdf. Online link.
21) Dilara Sen, Albert J. Keung, Designing epigenome editors: considerations of biochemical and locus specificities, Methods in Molecular Biology, 1767: 65-88, 2018. View pdf. Online link.
20) Jessica B. Lee, Albert J. Keung, Chromatin immunoprecipitation in human and yeast cells, Methods in Molecular Biology, 1767: 257-270, 2018. View pdf. Online link.
19) Minhee Park, Albert J. Keung, Ahmad S. Khalil, The epigenome: the next substrate for engineering, Genome Biology, 17:183, 2016. View pdf. Online link.
18) Albert J. Keung, Ahmad S. Khalil, A unifying model of epigenetic regulation, Science, (Perspective), 351:6274, 661-662, 2016. View pdf. Online link.
17) Albert J. Keung, J. Keith Joung, Ahmad S. Khalil, James J. Collins, Chromatin regulation at the frontier of eukaryotic synthetic biology, Nature Reviews Genetics, 16:159-171, 2015. View pdf. Online link.
16) Albert J. Keung, Caleb J. Bashor, Szilvia Kiriakov, James J. Collins, Ahmad S. Khalil, Using Targeted Chromatin Regulators to Engineer Combinatorial and Spatial Transcriptional Regulation, Cell, 158: 110-120, 2014. View pdf. Online link. Journal Cover.Press. Research Highlight in Nature Review Genetics (pdf).
15) Albert J. Keung, Meimei Dong, David V. Schaffer#, Sanjay Kumar#, Pan-neuronal Maturation but not Neuronal Subtype Differentiation of Adult Neural Stem Cells is Mechanosensitive, Scientific Reports, 3:1817, 2013. View pdf. Online link.
14) Albert J. Keung, Prashanth Asuri, Sanjay Kumar#, David V. Schaffer#, Soft Substrates Promote the Early Neurogenic Differentiation but not Self-Renewal of Human Pluripotent Stem Cells, Integrative Biology, 4:1049-1058, 2012. View pdf. Online link.
13) Joanna L. MacKay, Albert J. Keung, Sanjay Kumar, A Genetic Strategy for Dynamic and Graded Control of Cell Mechanics, Motility, and Matrix Remodeling, Biophysical Journal, 102(3):434-442, 2012. View pdf. Online link.
12) Albert J. Keung*, Elena de Juan Pardo*, David V. Schaffer#, Sanjay Kumar#, Rho GTPases Mediate the Mechanosensitive Lineage Commitment of Neural Stem Cells, Stem Cells, 29:1886-1897, 2011. View pdf. Online link.
11) Jae-Hyung Jang, James T Koerber, Jung-Suk Kim, Prashanth Asuri, Tandis Vazin, Melissa Bartel, Albert Keung, Inchan Kwon, Kook In Park, David V Schaffer, An Evolved Adeno-Associated Viral Variant Enhances Gene Delivery and Gene Targeting in Neural Stem Cells, Molecular Therapy, 19(4):667-75, 2011. View pdf. Online link.
10) Joseph L. Peltier, Anthony Conway, Albert J. Keung, David V. Schaffer, Akt Increases Sox2 Expression in Adult Hippocampal Neural Progenitor Cells but Increased Sox2 does not Promote Proliferation, Stem Cells and Development, 20(7):1153-61, 2011. View pdf. Online link.
9) Randolph S. Ashton, Albert J. Keung, Joseph L. Peltier, David V. Schaffer, Progress and Prospects for Stem-Cell Engineering, The Annual Review of Chemical and Biomolecular Engineering, 2:479-502, 2011. View pdf. Online link.
8) Albert J. Keung, Sanjay Kumar#, David V. Schaffer#, Presentation Counts: Microenvironmental Regulation of Stem Cells by Biophysical and Material Cues, The Annual Review of Cell and Developmental Biology, 26:533-556, 2010. View pdf. Online link.
7) Wilbur A. Lam, Lizhi Cao, Vaibhavi Umesh, Albert J. Keung, Shamik Sen, and Sanjay Kumar, Extracellular matrix rigidity modulates neuroblastoma cell differentiation and N-Myc expression, Molecular Cancer, 9:35, 2010. View pdf. Online link.
6) Albert J. Keung, Kevin E. Healy, Sanjay Kumar, David V. Schaffer, Biophysics and dynamics of natural and engineered stem cell microenvironments, Wiley Interdisciplinary Reviews: Systems Biology and Medicine, 2009. View pdf. Online link.
5) Krishanu Saha, Albert J. Keung*, Elizabeth F. Irwin*, Yang Li, Lauren Little, David V. Schaffer#, and Kevin E. Healy#, Substrate Modulus Directs Neural Stem Cell Behavior, Biophysical Journal, 2008, 95, 9, 4426-4438. View pdf. Online link.
4) Albert J. Keung, Michael A. Filler, and Stacey F. Bent, Thermal Control of Amide Product Distributions at the Ge(100)-2×1 Surface, Journal of Physical Chemistry C, 2007, 111, 411-419. View pdf. Online link.
3) Michael A. Filler, James A. Van Deventer, Albert J. Keung, and Stacey F. Bent, Carboxylic Acid Chemistry at the Ge(100)-2×1 Interface: Bidentate Bridging Structure Formation on a Semiconductor Surface, Journal of the American Chemical Society, 2006, 128(3), 770-779. View pdf. Online link.
2) Michael A. Filler, Albert J. Keung, David W. Porter, and Stacey F. Bent, Formation of Surface-bound Acyl Groups by Reaction of Acyl Halides on Ge(100)-2×1, Journal of Physical Chemistry B, 2006, 110, 4115-4124. View pdf. Online link.
1) Albert J. Keung, Michael A. Filler, David W. Porter, and Stacey F. Bent, Tertiary amide chemistry at the Ge(100)-2×1 surface, Surface Science, 599, 2005, 41-54. View pdf. Online link.
* Co-authors, # Co-corresponding