The Keung Lab
We are a synthetic biology group that is interested in the complex gene regulatory behaviors that are encoded by the epigenome and chromatin systems. These include the properties of gene expression memory, genetic imprinting, and dynamic signal processing. To study these properties, we develop molecular approaches to interface with and perturb the epigenome of cells. In addition, we are applying these tool to understand disease mechanisms, particularly in neural systems. We have ongoing projects related to: Autism, Angelman Syndrome, and Addiction; basic chromatin mechanisms in yeast; and exploiting DNA as a potential extreme-density storage medium for digital information.